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李广存

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姓 名: 李广存
职 称: 研究员
电 话: 010-82105955
邮 箱: liguangcun@caas.cn
研究方向: 马铃薯遗传育种与种质创制
最高学历: 农学博士
导师类别: 硕士、博士导师
研究领域: 蔬菜学

个人简介

       1972年7月生,山东省菏泽人,博士、研究员、博士生导师、中国农业科学院“创新型领军人才”。1995年获东北农业大学学士学位,2002年获山东大学硕士学位,2006年获中国农科院博士学位。1995年7月至2014年12月在山东省农业科学院工作,2015年1月被人才引进至中国农科院蔬菜花卉研究所。现任中国农科院蔬菜花卉研究所马铃薯遗传育种与栽培创新团队首席科学家和课题组长、农业农村部薯类作物生物学和遗传育种重点实验室副主任;兼任国家马铃薯产业科技创新联盟秘书长,中国作物学会马铃薯专业委员会副秘书长兼生物技术学部部长、中国农科院园艺学科学位评定委员会委员等。

       主要从事马铃薯种质资源的筛选评价、新种质创制和分子育种工作,并在马铃薯新种质创制、基因组学、重要性状遗传解析与基因挖掘、马铃薯与病原分子互作等方面取得了重要成果。先后获得省部级以上科技奖励6项,其中国家科技进步二等奖1项。在Nature、Nature Genetics、Molecular plant、Plant Cell、Plant Biotechnology Journal、中国农业科学等期刊上发表论文100余篇(其中SCI收录40余篇)。


科研情况

      针对马铃薯关键共性技术瓶颈和产业问题,以为马铃薯产业绿色健康发展提供理论支撑和关键技术为目标,从马铃薯种质资源收集评价到新品种培育的多个环节开展研究。评价筛选和创制了马铃薯抗病抗逆优质等特异新种质100余份;创建了高通量BAC-end测序辅助基因组组装和物理图谱构建新方法,构建了茄科作物第一张基因组完成图(Potato-T2T/DM8.1),联合开发了异交植物基因高效定位新算法工具OcBSA,主要骨干参与完成了四倍体普通栽培种马铃薯的基因组图谱绘制等,为马铃薯的遗传育种研究奠定了基因组学基础;定位克隆了R3b、StGolS1、StNADC、Ro等抗晚疫病、耐寒、熟性、薯形等重要性状的功能基因(位点),初步解析了马铃薯抗晚疫病、抗旱、耐寒、优质及表观等性状的遗传基础,突破了同源四倍体难以进行标记开发和重要性状遗传解析的难题,建立了抗病、抗逆、熟性等标记辅助育种体系并用于马铃薯新品种培育。集成创新了水肥高效利用的栽培管理技术,主要完成人育成了中薯27、中薯49、中薯早35、中薯早39等多个马铃薯新品种。已培养研究生和博士后24人,已毕业12人,在读在站研究生博士后14人。

主要成果

  1. Zhang LK†; Duan YF†; Zhang ZW; Zhang L; Chen SM; Cai CC; Duan SG; Zhang K; Li GC*; Cheng F*. OcBSA: an NGS-based Bulk Segregant Analysis Tool for Outcross Populations. Molecular Plant. 2024, https://doi.org/10.1016/j.molp.2024.02.011.

  2. Hu J, Duan YF, Hu JX, Zhang SQ, Li GC* Identification and expression analysis of the sucrose synthase and sucrose phosphate synthase gene family in potato. Metabolites. 2024, 14, 70. https://doi.org/10.3390/metabo14010070

  3. Yan WY†, Qin JH†, Jian YQ, Liu JG, Bian CS, Jin LP, Li GC*. Analysis of Potato Physiological and Molecular Adaptation in Response to Different Water and Nitrogen Combined Regimes. Plants. Plants 2023, 12, 1671. https://doi.org/10.3390/plants12081671

  4. Yang XH†, Zhang LK†, Guo X, Xu JF, Zhang K, Yang YQ, Yang Y, Jian YQ, Dong DF, Huang SW, Cheng F*, and Li GC*. The gap-free potato genome assembly reveals large tandem gene clusters of agronomical importance in highly repeated genomic regions. Molecular Plant, 2023, 16, 314–317. https://doi.org/10.1016/j.molp.2022.12.010

  5. Bao ZG†, Li CH†, Li GC, Wang P, Peng Z, Cheng L, Li HB, Zhang ZY, Li YY, Huang W, Ye MW, Dong DF, Cheng ZK, Peter VanderZaag, Jacobsen Evert, Christian W. B. Bachem, Dong SM, Zhang CZ, Huang SW*, and Zhou Q*. Genome architecture and tetrasomic inheritance of autotetraploid potato. Molecular Plant, 2022, 15, 1211–1226.

  6. Yang XH†, Yang Y†, Ling J, Guan JT, Guo X, Dong DF, Jin LP, Huang SW, Liu J * and Li GC*. A high-throughput BAC-end analysis protocol (BAC-anchor) for profiling genome assembly and physical mapping. Plant Biotechnology Journal, 2020 (18): 364–372.

  7. He FY, Xu JF, Jian YQ, Duan SG, Hu J, Jin LP*, and Li GC*. Overexpression of galactinol synthase 1 from Solanum commersonii (ScGolS1) confers freezing tolerance in transgenic potato, Horticultural Plant Journal, 2022, doi: doi.org/10.1016/j.hpj.2022.05.005

  8. He FY†, Duan SG†, Jian YQ, Xu JF, Hu J, and Li GC*. Genome-wide identification, structural and gene expression analysis of the 14-3-3 gene family in Potato (Solanum tuberosum L.). BMC Genomics, 2022. 23:811 https://doi.org/10.1186/s12864-022-09037-y

  9. Fan GY†, Wang QR†, Xu JF, Chen N, Zhu WW, Duan SG, Walter S De Jong, Jin LP*, and Li GC*. Fine mapping and candidate gene prediction of tuber shape controlling Ro locus based on integrating genetic and transcriptomic analyses in potato. International Journal of Molecular Science, 2022, 23, 1470. https://doi.org/10.3390/ijms23031470

  10. Yan WY†, Jian YQ†, Duan SG, Guo X, Hu J, Yang XH*, and Li GC*. Dissection of plant hormone signal transduction network in late blight resistance potato genotype SD20 and prediction of key resistance genes. Phytopathology, 2022. https://doi.org/10.1094/PHYTO-04-22-0124-R

  11. Yang Y†, Yang XH†, Guo X, Hu XX, Dong DF, Li GC*, Xiong XY*. Exogenously applied methyl jasmonate induces early defense related genes in response to Phytophthora infestans infection in potato plants, Horticultural Plant Journal, 2022, doi: https://doi.org/10.1016/j.hpj.2022.04.003

  12. Hui ZM, Xu JF, Jian YQ, Bian CS, Duan SG, Hu J, Li GC* and Jin LP*. Identification of long-distance transport signal molecules associated with the plant maturity of tetraploid cultivated potato (Solanum tuberosum L.). Plants. 2022. 11, 1707. https://doi.org/10.3390/plants11131707

  13. Qin JH, Bian CS, Duan SG, Wang WX, Li GC*, and Jin LP*. Effects of different rotation cropping systems on potato yield, rhizosphere microbial community and soil biochemical properties. Frontiers in Plant Science,2022, 13:999730. https://doi.org/10.3389/fpls.2022.999730

  14. Jian YQ, Yan WY, Xu JF, Duan SG, Li GC*, and Jin LP*. Genome-wide simple sequence repeat markers in potato: abundance, distribution, composition, and polymorphism. DNA Research, 2021, 28(6) dsab020, https://doi.org/10.1093/dnares/dsab020

  15. Duan YF, Duan SG, Xu JF, Zheng JY, Hu J, Li BJ, Li GC*, and Jin LP*. Late blight resistance evaluation and genome-wide assessment of genetic diversity using SSR and SNP markers in wild and cultivated potato species. Frontiers in Plant Science, 2021. 12: 710468. doi: 10.3389/fpls.2021.710468

  16. Zheng JY, Duan SG, Armstrong MR, Duan YF, Xu JF, Chen XW, Hein I, Jin LP* and Li GC*. New findings on the resistance mechanism of an elite diploid wild potato species JAM1-4 in response to a super race strain of Phytophthora infestans. Phytopathology, 2020,110. doi: 10.1094/PHYTO-09-19-0331-R.

  17. Zheng JY, Yang Y, Guo X, Jin LP, Xiong XY, Yang XH*, and Li GC*. Exogenous SA initiated defense response and multi-signaling pathway in tetroploid potato SD20. Horticultural Plant Journal, 2020. 6 (2): 111–122.

  18. Yang XH†, Chen L†, Yang Y, Guo X, Chen GX, Xiong XY, Dong DF*, and Li GC*. Transcriptome analysis reveals that exogenous ethylene activates immune and defense responses in a high late blight resistant potato genotype. Scientific Reports, 2020, 10:21294. doi.org/10.1038/s41598-020-78027-5.

  19. Yang XH, Guo X, Chen GX, Dong DF, Liu F, Yang YJ, Yang Y* and Li GC*. Comparison of defense responses of transgenic potato lines expressing three different Rpi genes to specific Phytophthora infestans races based on transcriptome profiling. PeerJ, 2020. 8:e9096 http://doi.org/10.7717/peerj.9096

  20. Hou Q, Wang WX, Yang Y, Hu J, Bian CS, Jin LP, Li GC*, and Xiong XY*. Correlation analysis of rhizosphere microbial diversity and soil physical-chemical properties provides insight into fertilization management during potato cultivation”. European Journal of Soil Biology, 2020, (98) 103176. doi.org/10.1016/j.ejsobi.2020.103176

  21. Duan YF, Duan SG, Xu JF, Zheng JY, Hu J, Li GC*, and Jin LP*. Comparative transcriptome profiling reveals compatible and incompatible patterns of potato toward Phytophthora infestans. G3/Genes Genomes Genetics, 2020 (10): 623-634.

  22. “早熟优质多抗马铃薯新品种选育与应用”获2017年度国家科技进步二等奖(排名第5)

  23. “抗病耐冻早熟马铃薯育种技术的建立及新品种选育” 获2015年度中华农业科技一等奖(排名第7)

科研项目(近五年)

  1. 国家重点研发课题(主持):马铃薯优质多抗新种质创制与应用(2023YFD1201505),297万元,2023.10-2027.12

  2. 国家马铃薯产业技术体系岗位科学家(CARS-9-P11,主持),315万元,2021.1-2025.12

  3. 国家自然科学基金面上项目(主持):StNADC1基因及其互作蛋白共调控马铃薯植株生理成熟的分子机制研究(32072119),69.6万元,2021.1-2024.12

  4. 国家自然科学基金国际合作重点项目(主持):马铃薯重要农艺性状遗传区段解析与优异种质发掘(31561143006),273.2万元,2016.1-2020.12

  5. 中国农业科学院“创新型领军人才”项目(主持),400万元,2024.1-2028.12

  6. 中国农业科学院创新工程项目(主持):马铃薯遗传育种与栽培创新团队(CAAS-ASTIP-IVFCAAS),650万元,2022.1-2026.12

 

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